Gu Q, Wang D, Cui C, Gao Y, Xia G, Cui X
Institute of Radiation Medicine, Beijing, PR China.
J Environ Pathol Toxicol Oncol. 1998;17(2):117-23.
The pathological changes of radiation on wound healing in rats were observed by macroscopic, microscopic, and electronmicroscopic examination and detection of collagen types. We found that the wound healing process was obviously delayed by irradiation. First, the early phase inflammatory response was severely inhibited. In particular, the number of infiltrating macrophages and neutrophils was decreased, blood vessels were injured, and hemorrhage was evident. Second, the formation and maturation of granulation tissue were slowed down, fibroblasts were injured, and transcription of types and collagen mRNAs and synthesis and secretion of collagen were reduced. Finally, the reepithelialization process was delayed and the healing time was prolonged.
通过大体观察、显微镜检查、电子显微镜检查以及胶原类型检测，观察了辐射对大鼠伤口愈合的病理变化。我们发现，照射明显延迟了伤口愈合过程。首先，早期炎症反应受到严重抑制。特别是，浸润的巨噬细胞和中性粒细胞数量减少，血管受损，出血明显。其次，肉芽组织的形成和成熟减缓，成纤维细胞受损，胶原类型和胶原mRNA的转录以及胶原的合成和分泌减少。最后，再上皮化过程延迟，愈合时间延长。
