Urban P, Verin V, Popowski Y, Rutishauser W
Cardiology Center, University Hospital, Geneva, Switzerland.
Semin Interv Cardiol. 1997 Jun;2(2):125-31.
We have developed a technique of endoluminally centred endovascular beta irradiation aimed at preventing restenosis after PTCA. The source consists of a pure metallic 90-Yttrium coil that can be positioned within the lumen at the target site by the use of a centering device and an afterloading console. Experimental evaluation of this approach showed that a dose of 18 Gy delivered at the inner arterial surface was highly effective in preventing fibrointimal hyperplasia in rabbit carotid and iliac arteries. A pilot clinical evaluation in the coronary arteries of 15 patients using the same dose demonstrated excellent feasibility and no unexpected side-effects. A dose-finding evaluation in the clinical setting is now planned.
我们已经开发出一种腔内中心性血管内β射线照射技术，旨在预防经皮冠状动脉腔内血管成形术（PTCA）后的再狭窄。该放射源由一个纯金属钇线圈组成，通过使用一个定心装置和一个后装控制台，可将其放置在目标部位的管腔内。对该方法的实验评估表明，在内动脉表面给予18 Gy的剂量在预防兔颈动脉和髂动脉纤维内膜增生方面非常有效。对15例患者的冠状动脉进行的初步临床评估显示，使用相同剂量具有极佳的可行性，且未出现意外副作用。目前计划在临床环境中进行剂量探索评估。
