Levy G, Mak C C, Nhean H
Ann Anesthesiol Fr. 1979;20(9):784-8.
High molecular weight (approximately 60,000) dextran having been selected in a protocol of per-operative hemodilution, a prior study was undertaken in vitro in order to measure the variations in parameters of hemostasis. Factor of primary hemostasis, of plasma coagulation and fibrinolysis were thus evaluated in control blood samples, not diluted and diluted to 1/5 th by dextran or by a buffer solution. Statistical analysis was carried out using the t-test for pairs of variables. The following emerge from the results: 1 - an absence of difference with regard to the fibrinolytic activity of the plasma, but marked fragility of the fibrin clot in the presence of dextran; 2 - variations for plasma coagulation factors due to dilution; 3 - acceleration of the phase of polymerisation of fibrin monomeres and a decrease in platelet stickiness and aggregation due to dextran.
在一项术中血液稀释方案中选择了高分子量（约60,000）的右旋糖酐，此前进行了一项体外研究以测量止血参数的变化。因此，在未稀释以及用右旋糖酐或缓冲溶液稀释至五分之一的对照血样中评估了初级止血、血浆凝血和纤维蛋白溶解因子。使用t检验对变量进行统计分析。结果如下：1 - 血浆纤维蛋白溶解活性没有差异，但在存在右旋糖酐的情况下纤维蛋白凝块明显易碎；2 - 稀释导致血浆凝血因子发生变化；3 - 右旋糖酐导致纤维蛋白单体聚合阶段加速，血小板黏附性和聚集性降低。
