Fisher J R, Stewart T A, Wu J M, Nickels J S, High J A
Enzyme. 1976;21(5):385-96. doi: 10.1159/000458888.
It is well-known that in the chick, dietary protein increases the levels of several hepatic enzymes that are involved in nitrogen metabolism and excretion. However, the biochemical mechanism of this response is essentially unknown. The experiments presented in this paper show that the chick is responding to alpha-amino nitrogen and not to any specific amino acid. Furthermore, it is shown that this system responds to endogenous sources of nitrogen as well as dietary protein and that the xanthine dehydrogenase response involves regulation of enzyme synthesis without changing the rate of degradation.
众所周知，在雏鸡中，膳食蛋白质会增加几种参与氮代谢和排泄的肝脏酶的水平。然而，这种反应的生化机制基本上尚不清楚。本文所呈现的实验表明，雏鸡对α-氨基氮有反应，而不是对任何特定的氨基酸有反应。此外，研究表明，该系统对内源氮源以及膳食蛋白质都有反应，并且黄嘌呤脱氢酶的反应涉及酶合成的调节，而不改变降解速率。
