Wolfe R R, Horvath S M
Eur J Appl Physiol Occup Physiol. 1976 Jun 21;35(2):159-66. doi: 10.1007/BF02333806.
Previous investigations of polycythemia in rodents failed to delineate the effects of the increased hematocrits from the effects of possible changes in blood volume. The hemodynamic responses of anesthetized rats to acutely produced increases in hematocrit and blood volume were therefore studied in this experiment. Acute isovolumetric polycythemia decreased O2 transport from a control value of 44.9 to 35.1 ml/min/kg 60 min after the exchange-transfusion. However, the high venous O2 content (over 12 Vol.-%) following the production of isovolumetric polycythemia suggested that there was still sufficient oxygen available to the tissues. Hypervolemia significantly modified the response to acute polycythemia. When hematocrit was maintained at a constant level, acute hypervolemia increased O2 transport (to 54.6 ml/min/kg after 60 min), and when acute hypervolemia and polycythemia were induced simultaneously, O2 transport was transiently increased (to 57.5 ml/min/kg after 15 min) and then returned to a value similar to the control level.
以往对啮齿动物红细胞增多症的研究未能将血细胞比容升高的影响与血容量可能变化的影响区分开来。因此，在本实验中研究了麻醉大鼠对急性产生的血细胞比容和血容量增加的血流动力学反应。急性等容性红细胞增多症使换血后60分钟时的氧气运输量从对照值44.9降至35.1毫升/分钟/千克。然而，等容性红细胞增多症产生后高静脉血氧含量（超过12体积%）表明组织仍有足够的氧气供应。血容量过多显著改变了对急性红细胞增多症的反应。当血细胞比容维持在恒定水平时，急性血容量过多会增加氧气运输量（60分钟后增至54.6毫升/分钟/千克），当同时诱导急性血容量过多和红细胞增多症时，氧气运输量会短暂增加（15分钟后增至57.5毫升/分钟/千克），然后恢复到与对照水平相似的值。
