活性氧参与磷脂酶A2激活：对蛋白酪氨酸磷酸酶的抑制及蛋白激酶的激活。
Involvement of reactive oxygen species in phospholipase A2 activation: inhibition of protein tyrosine phosphatases and activation of protein kinases.
作者信息
Goldman R, Ferber E, Zor U
机构信息
Department of Membrane Research and Biophysics, Weizmann Institute of Science, Rehovot, Israel.
出版信息
Adv Exp Med Biol. 1997;400A:25-30. doi: 10.1007/978-1-4615-5325-0_4.
PMID:9547533
Abstract
Activators of PKC in combination with vanadate induce massive formation of reactive oxygen species. The formation of ROS leads to suppression of protein tyrosine phosphatase activity and consequently to enhanced protein tyrosine phosphorylation. This culminates in the activation of the MAP-K cascade and of PLA2 (Scheme 1).
摘要
蛋白激酶C激活剂与钒酸盐联合使用会诱导大量活性氧的形成。活性氧的形成会导致蛋白酪氨酸磷酸酶活性受到抑制，进而导致蛋白酪氨酸磷酸化增强。这最终会导致丝裂原活化蛋白激酶级联反应和磷脂酶A2的激活（方案1）。
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