Korbecki Jan, Baranowska-Bosiacka Irena, Gutowska Izabela, Chlubek Dariusz
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp. 72 Av., 70-111 Szczecin, Poland.
Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Broniewskiego 24 Str., 71-460 Szczecin, Poland.
Int J Mol Sci. 2015 Jun 4;16(6):12648-68. doi: 10.3390/ijms160612648.
This paper discusses how the activity and expression of cyclooxygenases are influenced by vanadium compounds at anticancer concentrations and recorded in inorganic vanadium poisonings. We refer mainly to the effects of vanadate (orthovanadate), vanadyl and pervanadate ions; the main focus is placed on their impact on intracellular signaling. We describe the exact mechanism of the effect of vanadium compounds on protein tyrosine phosphatases (PTP), epidermal growth factor receptor (EGFR), PLCγ, Src, mitogen-activated protein kinase (MAPK) cascades, transcription factor NF-κB, the effect on the proteolysis of COX-2 and the activity of cPLA2. For a better understanding of these processes, a lot of space is devoted to the transformation of vanadium compounds within the cell and the molecular influence on the direct targets of the discussed vanadium compounds.
本文讨论了在抗癌浓度下钒化合物如何影响环氧化酶的活性和表达，并记录在无机钒中毒情况中。我们主要提及钒酸盐（原钒酸盐）、氧钒根和过氧钒酸根离子的作用；主要关注点在于它们对细胞内信号传导的影响。我们描述了钒化合物对蛋白酪氨酸磷酸酶（PTP）、表皮生长因子受体（EGFR）、磷脂酶Cγ（PLCγ）、Src、丝裂原活化蛋白激酶（MAPK）级联反应、转录因子NF-κB的作用机制，以及对COX-2蛋白水解和胞质磷脂酶A2（cPLA2）活性的影响。为了更好地理解这些过程，本文用了大量篇幅阐述钒化合物在细胞内的转化以及对所讨论的钒化合物直接靶点的分子影响。
