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用苄丝肼和左旋多巴预处理的犬对急性缺氧的心血管反应。

Cardiovascular responses to acute hypoxia in dogs pretreated with benserazide and L-DOPA.

作者信息

Boismare F, Le Poncin M, Hacpille L

出版信息

Eur J Pharmacol. 1976 Jul;38(1):1-5. doi: 10.1016/0014-2999(76)90194-1.

DOI:10.1016/0014-2999(76)90194-1
PMID:954818
Abstract

In the control dogs, hypoxia induced different hemodynamic modifications (i.e. an increase of arterial blood pressure, heart rate, cardiac output, regional blood flow) which seem to be related to a release of epinephrine. Pretreatment with benserazide (20 mg/kg i.v.) and L-Dopa (50 mg/kg i.p.) either lessened or completely suppressed any sign of sympathetic stimulation. These results suggest that chemoreceptors are centrally inhibited as had been previously proved for baroreceptors.

摘要

在对照犬中,低氧诱导了不同的血流动力学改变(即动脉血压、心率、心输出量、局部血流增加),这些改变似乎与肾上腺素的释放有关。用苄丝肼(20毫克/千克静脉注射)和左旋多巴(50毫克/千克腹腔注射)预处理可减轻或完全抑制任何交感神经刺激的迹象。这些结果表明,化学感受器受到中枢抑制,这正如先前对压力感受器所证明的那样。

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