Misson J, Kendall M J
Department of Medicines Management, Keele University, UK.
J Clin Pharm Ther. 1997 Aug;22(4):251-5. doi: 10.1046/j.1365-2710.1997.10275102.x.
Until recently, few drugs have been available for the treatment of Alzheimer's disease. The first such drug to be launched in the U.K. was the acetylcholinesterase inhibitor, donepezil. The limited published data on donepezil shows only modest cognitive benefit in patients with Alzheimer's disease. The cost of diagnosis and drug treatment, the distressing nature of the disease and the limited evidence available, pose difficult decisions for the introduction of new drugs and the management of this condition.
直到最近，用于治疗阿尔茨海默病的药物还很少。在英国推出的第一种此类药物是乙酰胆碱酯酶抑制剂多奈哌齐。关于多奈哌齐的已发表数据有限，仅显示对阿尔茨海默病患者有适度的认知益处。诊断和药物治疗的成本、该疾病令人痛苦的性质以及可用证据有限，给新药的引入和这种疾病的管理带来了艰难的决策。
