阿扑吗啡和匹莫齐特对麻醉犬肾素分泌的影响。
Effects of apomorphine and of pimozide on renin secretion in the anaesthetized dog.
作者信息
Imbs J L, Schmidt M, Velly J, Schwartz J
出版信息
Eur J Pharmacol. 1976 Jul;38(1):175-8. doi: 10.1016/0014-2999(76)90214-4.
This paper presents the results of a study of the receptors involved in renin hypersecretion induced by dopamine. Apomorphine induces renin hypersecretion without significantly modifying the renal blood flow. This renin hypersecretion is inhibited by haloperidol. However, pimozide, a selective dopaminolytic agent, is incapable of inhibiting the renin hypersecretion induced by dopamine. These results provide supplementary evidence for the existence of renal dopaminergic receptors which would appear to differ from the central dopaminergic receptors.
本文介绍了一项关于多巴胺诱导肾素分泌过多所涉及的受体的研究结果。阿扑吗啡可诱导肾素分泌过多，而对肾血流量无显著影响。这种肾素分泌过多可被氟哌啶醇抑制。然而，选择性多巴胺能阻滞剂匹莫齐特却无法抑制多巴胺诱导的肾素分泌过多。这些结果为肾多巴胺能受体的存在提供了补充证据，这些受体似乎与中枢多巴胺能受体不同。
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