L-α-氨基-β-氯丙酸羟肟酸：一种γ-氨基丁酸-α-酮戊二酸转氨酶抑制剂。
L-alpha-amino-beta-chloropropionic acid hydroxamide: an inhibitor of GABA-lapha-oxoglutarate aminotrarsferase.
作者信息
Tsui D, Gorecki D K, Charington C B, Wood J D
出版信息
Eur J Pharmacol. 1976 Jul;38(1):189-92. doi: 10.1016/0014-2999(76)90217-x.
PMID:954828
Abstract
The intramuscular administration of L-alpha-amino-beta-chloropropinonic acid hydroxamide (2 mmol/kg) to mice strongly inhibited the activity of GABA-T, but not GAD, in the brain of the animals. Adminstration of the compound 3 h prior to isonicotinic acid hydrazide treatment significantly delayed the onset of seizures induced by the hydrazide.
摘要
给小鼠肌肉注射L-α-氨基-β-氯丙氨酸羟胺（2毫摩尔/千克）可强烈抑制动物脑中GABA-T的活性，但不影响GAD的活性。在异烟肼治疗前3小时给予该化合物可显著延迟由异烟肼诱导的癫痫发作的开始时间。
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