Ichikawa M, Maeda T, Handa J
Department of Neurosurgery, Shiga University of Medical Science, Otsu, Japan.
Childs Nerv Syst. 1998 Jan-Feb;14(1-2):21-5. doi: 10.1007/s003810050168.
We examined the changes in ornithine decarboxylase (ODC) immunoreactivity in the hydrocephalic cerebral cortex of HTX rats after decompression by shunt operation. The ODC immunoreactivity reached a very low level after the completion of cortical layer formation, and only faint staining was found on postnatal day (Pd) 11. The ODC immunoreactivity re-appeared after the shunt operation when the operation was done in the early days of life: the ODC immunoreactivity was first found on day 2 after shunting and persisted until day 8 after shunting. However, this was not apparent when the operation was not performed until Pd 14. The re-expression of ODC in hydrocephalic brain after shunting appears to cause resumption of the developmental process by relieving neurons from increased hydrostatic pressure. The dependence of ODC re-expression on the timing of the operation indicates that there may be a period of neocortical decompression that is critical for effective compensatory development, so that when delayed, decompression fails to re-activate the ODC-dependent development.
我们研究了分流手术后HTX大鼠脑积水大脑皮质中鸟氨酸脱羧酶（ODC）免疫反应性的变化。在皮质层形成完成后，ODC免疫反应性达到非常低的水平，在出生后第11天仅发现微弱染色。当在生命早期进行分流手术时，术后ODC免疫反应性重新出现：分流后第2天首次发现ODC免疫反应性，并持续至分流后第8天。然而，当直到出生后第14天才进行手术时，这种情况并不明显。分流后脑积水大脑中ODC的重新表达似乎通过减轻神经元静水压力增加而导致发育过程恢复。ODC重新表达对手术时机的依赖性表明，可能存在一个对有效代偿性发育至关重要的新皮质减压期，因此当延迟时，减压无法重新激活ODC依赖性发育。
