长期左旋肉碱治疗对自发性高血压大鼠血压和血脂的影响。
The effect of chronic L-carnitine treatment on blood pressure and plasma lipids in spontaneously hypertensive rats.
作者信息
Rauchová H, Dobesová Z, Drahota Z, Zicha J, Kunes J
机构信息
Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska, Prague.
出版信息
Eur J Pharmacol. 1998 Jan 26;342(2-3):235-9. doi: 10.1016/s0014-2999(97)01505-7.
The effect of chronic L-carnitine treatment on blood pressure and plasma lipids was studied in spontaneously hypertensive rats (SHR). L-Carnitine treatment for 6 weeks lowered significantly both the systolic and mean arterial pressure of SHR but its influence on diastolic and pulse pressure was only modest. L-Carnitine did not influence the relative heart and kidney weight of SHR. However, L-carnitine completely abolished the age-dependent rise of plasma total cholesterol, triglycerides and uric acid seen in untreated SHR. On the other hand, L-carnitine treatment had no significant effects on blood pressure, relative organ weight and plasma lipids in normotensive Wistar-Kyoto rats. Our results suggest that L-carnitine might prevent some cardiovascular alterations by its influence on lipid metabolism.
研究了长期左旋肉碱治疗对自发性高血压大鼠（SHR）血压和血脂的影响。左旋肉碱治疗6周可显著降低SHR的收缩压和平均动脉压，但其对舒张压和脉压的影响较小。左旋肉碱不影响SHR的相对心脏和肾脏重量。然而，左旋肉碱完全消除了未治疗SHR中出现的血浆总胆固醇、甘油三酯和尿酸随年龄的升高。另一方面，左旋肉碱治疗对正常血压的Wistar-Kyoto大鼠的血压、相对器官重量和血脂没有显著影响。我们的结果表明，左旋肉碱可能通过其对脂质代谢的影响来预防一些心血管改变。
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