Lindsetmo R O, Johnsen R, Revhaug A
Dept. of Gastrointestinal Surgery, Tromsø University Hospital, Norway.
Scand J Gastroenterol. 1998 Mar;33(3):231-5. doi: 10.1080/00365529850170775.
The Maastricht Consensus Report advises that, in Helicobacter pylori-positive patients after surgery for peptic ulcer disease, H. pylori should be eradicated. The aim of the present study was to investigate the symptomatic response of H. pylori eradication in previously vagotomized peptic ulcer patients with persistent dyspeptic complaints.
The study was performed as a randomized, double-blind, placebo-controlled study. Pretreatment diagnostic upper endoscopy was omitted. All the results were submitted to intention-to-treat and efficacy analyses.
We could not find any differences between the two groups with regard to intensity or frequency of upper abdominal pain, nausea, heartburn, or other abdominal symptoms during the 12-month follow-up. The triple therapy eradication rate was 88% at both 3- and 12-month controls.
Vagotomized peptic ulcer patients with persistent dyspeptic complaints should undergo a diagnostic upper endoscopy to detect ulcer recurrence before H. pylori eradication treatment is considered.
《马斯特里赫特共识报告》建议，对于消化性溃疡病手术后幽门螺杆菌阳性的患者，应根除幽门螺杆菌。本研究的目的是调查在先前已行迷走神经切断术且仍有持续性消化不良症状的消化性溃疡患者中，根除幽门螺杆菌后的症状反应。
本研究为随机、双盲、安慰剂对照研究。省略了治疗前的诊断性上消化道内镜检查。所有结果均进行意向性分析和疗效分析。
在12个月的随访期间，两组在上腹部疼痛、恶心、烧心或其他腹部症状的强度或频率方面未发现任何差异。三联疗法在3个月和12个月时的根除率均为88%。
对于有持续性消化不良症状的迷走神经切断术后消化性溃疡患者，在考虑进行幽门螺杆菌根除治疗之前，应进行诊断性上消化道内镜检查以检测溃疡复发。
