Russo F, Messa C, Amati L, Caradonna L, Leoci C, Di Matteo G, Jirillo E, Di Leo A
Laboratory of Biochemistry, IRCCS Saverio de Bellis, Castellana G. (Bari), Italy.
Scand J Gastroenterol. 1998 Mar;33(3):271-5. doi: 10.1080/00365529850170856.
The relationship between the expression of epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) and that of their receptor (EGF-R) in the Helicobacter pylori-infected gastric mucosa has not been completely elucidated. The aim of this study was to examine the interplay between H. pylori colonization and gastric mucosal growth factor content.
By means of a solid-phase enzyme-linked immunosorbent assay EGF, TGF-alpha, and EGF-R levels and interleukin-1beta (IL-1beta) content, which is considered a marker of chronic inflammation, were evaluated in the antral mucosa of 24 H. pylori-positive patients before and 8 weeks after eradication therapy.
After therapy H. pylori was eradicated in 19 patients. The eradication was accompanied by a significant decrease in IL-1beta content and an increase in EGF and TGF-alpha levels. On the other hand, in the five patients in whom the bacterium was not eradicated EGF, TGF-alpha, and EGF-R levels were quite similar to those assayed before therapy, whereas IL-1beta content was still high.
These results suggest that H. pylori exerts an inhibitory effect on the mucosal expression of EGF and TGF-alpha, which are likely involved in the gastric mucosa repair process.
幽门螺杆菌感染的胃黏膜中表皮生长因子（EGF）和转化生长因子-α（TGF-α）及其受体（EGF-R）表达之间的关系尚未完全阐明。本研究的目的是检测幽门螺杆菌定植与胃黏膜生长因子含量之间的相互作用。
采用固相酶联免疫吸附测定法，对24例幽门螺杆菌阳性患者根除治疗前及治疗8周后的胃窦黏膜中EGF、TGF-α、EGF-R水平以及作为慢性炎症标志物的白细胞介素-1β（IL-1β）含量进行评估。
治疗后19例患者的幽门螺杆菌被根除。根除伴随着IL-1β含量显著降低以及EGF和TGF-α水平升高。另一方面，在5例细菌未被根除的患者中，EGF、TGF-α和EGF-R水平与治疗前检测的水平相当，而IL-1β含量仍然很高。
这些结果表明，幽门螺杆菌对EGF和TGF-α的黏膜表达具有抑制作用，而EGF和TGF-α可能参与胃黏膜修复过程。
