Rodrigues D, Barros L, Ruas L, Gomes L, Geraldes E, Ruas M C
Serviço de Endocrinologia, Diabetes e Metabolismo, Hospitais da Universidade de Coimbra.
Acta Med Port. 1997 Nov;10(11):785-7.
To determine the prevalence of hypertension (HT) in patients with Cushing's syndrome.
We studied 23 patients with Cushing's syndrome, 17 women (mean +/- SD age = 42.8 +/- 15.6 years) and 6 men (mean +/- SD age = 34.8 +/- 10.2 years). The etiologies were: 16-Cushing's disease, 3-suprarenal adenoma, 2-suprarenal carcinoma and 2-iatrogenic. Blood pressure (BP) was measured at least three times and we consider hypertension when systolic BP > or = 140 mmHg and/or diastolic BP > or = 90 mmHg.
The prevalence of HT, at diagnosis, was 73.9% (64.7% in women and 100% in men) and the mean BP was 163 +/- 25/100 +/- 16 mmHg (158 +/- 26/97 +/- 15 mmHg in women and 182 +/- 5/114 +/- 10 mmHg in men). From the 16 patients with Cushing's disease, 13 (81%) had HT; all the patients (n = 3) with suprarenal adenoma had HT; none with suprarenal carcinoma (n = 2) had HT and only 1 of the 2 patients with iatrogenic Cushing's syndrome had HT. After treatment, 14 patients entered remission, 6 persisted with active disease and 1 was missed during the follow-up. In the group of patients that entered remission, the prevalence of HT at diagnosis was 78.5% (n = 11), 57.1% (n = 8) being after treatment.
In this study, we found a high prevalence of HT at diagnosis (73.9%). After treatment and in the patients that entered remission, the prevalence of HT remained high (78.5% vs 57.1%). The high prevalence of HT in Cushing's syndrome, suggests its importance as a morbidity factor and also as an important diagnostic indicator, when present.
确定库欣综合征患者中高血压（HT）的患病率。
我们研究了23例库欣综合征患者，其中17例女性（平均±标准差年龄=42.8±15.6岁），6例男性（平均±标准差年龄=34.8±10.2岁）。病因如下：16例为库欣病，3例为肾上腺腺瘤，2例为肾上腺癌，2例为医源性。血压（BP）至少测量三次，当收缩压≥140 mmHg和/或舒张压≥90 mmHg时，我们认定为高血压。
诊断时HT的患病率为73.9%（女性为64.7%，男性为100%），平均血压为163±25/100±16 mmHg（女性为158±26/97±15 mmHg，男性为182±5/114±10 mmHg）。在16例库欣病患者中，13例（81%）患有HT；所有肾上腺腺瘤患者（n=3）均患有HT；肾上腺癌患者（n=2）均无HT，2例医源性库欣综合征患者中只有1例患有HT。治疗后，14例患者病情缓解，6例仍患有活动性疾病，1例在随访期间失访。在病情缓解的患者组中，诊断时HT的患病率为78.5%（n=11），治疗后为57.1%（n=8）。
在本研究中，我们发现诊断时HT的患病率很高（73.9%）。治疗后以及病情缓解的患者中，HT的患病率仍然很高（78.5%对57.1%）。库欣综合征中HT的高患病率表明其作为发病因素的重要性，以及在存在时作为重要诊断指标的重要性。
