Szekanecz Z, Szegedi G, Koch A E
Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA.
J Investig Med. 1998 Feb;46(2):27-41.
In summary, angiogenesis, the formation of new blood vessels, is important in leukocyte extravasation and thus the pathogenesis of RA. The outcome of neovascularization highly depends on the imbalance between angiogenic and angiostatic mediators produced in the rheumatoid synovium. Therefore, angiogenesis research is important for the understanding of the pathogenesis of inflammatory arthritis. In addition, existing and potential angiostatic drugs may be useful for future therapy of RA.
总之，血管生成，即新血管的形成，在白细胞渗出以及类风湿性关节炎的发病机制中起着重要作用。新血管形成的结果高度依赖于类风湿滑膜中产生的促血管生成和血管生成抑制介质之间的失衡。因此，血管生成研究对于理解炎性关节炎的发病机制很重要。此外，现有的和潜在的血管生成抑制药物可能对类风湿性关节炎的未来治疗有用。
