单克隆抗体在药物递送系统中的应用——癌症的导弹疗法

[Application of monoclonal antibody for drug delivery system--missile therapy for cancer].

作者信息

Yamaguchi T, Takahashi T, Kitamura K, Otsuji E, Sakakura C, Okamoto K, Tsuruta H, Ichikawa D, Matsumura H, Yamamoto K, Nishida T, Kimura A

机构信息

Department of Surgery, Kyoto Prefectural University of Medicine.

出版信息

Nihon Rinsho. 1998 Mar;56(3):638-43.

PMID:9549349

Abstract

Clinical applications of monoclonal antibody for selective delivery of anticancer drug, toxin and radioisotope were reviewed. The difficulties in preparation and clinical application of chemoimmunoconjugate were pointed out. Also the difficulties of immunotoxin in clinical trial due to its high toxicity had been discussed and it is assumed that development of blocked ricin may overcome many problems related to toxicities. Clinically most advanced immunoconjugate seems to be radioimmunoconjugate. Among three types of immunoconjugates preparation of radioimmunoconjugate is easiest and some promising clinical trials were introduced in this review.

摘要

综述了单克隆抗体在抗癌药物、毒素和放射性同位素选择性递送方面的临床应用。指出了化学免疫缀合物在制备和临床应用中的困难。还讨论了免疫毒素由于其高毒性在临床试验中的困难，并认为开发封闭型蓖麻毒素可能克服许多与毒性相关的问题。临床上最先进的免疫缀合物似乎是放射免疫缀合物。在三种免疫缀合物类型中，放射免疫缀合物的制备最容易，本文综述了一些有前景的临床试验。