Ishida Y, Fukuchi K, Oka M, Sagoh M, Miyake Y, Hasimoto N
Nihon Rinsho. 1998 Mar;56(3):813-23.
Positron emission tomography (PET) has been providing new information in the diagnosis and the pathophysiological assessment of heart diseases. The PET tracers commonly used in Japan are 13N-ammonia, 18F-fluorodeoxyglucose (FDG) for imaging of myocardial perfusion and metabolism, respectively. Measurement of regional myocardial blood flow by 13N-ammonia dynamic PET scan and a compartment model analysis is applied to the functional estimation of coronary stenotic lesions and the detection of perfusion abnormalities in hypertrophic heart diseases, familial hyperchlesterolemia and other diseases with possible microvascular lesions. 18F-FDG is commonly used to differentiate ischemic but viable tissue from myocardial scar in coronary artery disease and also used to detect cardiac tumor and the cardiac involvement in sarcoidosis. In addition to these two tracers, 11C-acetate is now expected to provide the clinical analysis of pathophysiology of heart failure by estimating the efficiency of energy conversion of the heart into external work.
正电子发射断层扫描（PET）在心脏病的诊断和病理生理评估方面不断提供新信息。在日本常用的PET示踪剂分别是用于心肌灌注成像的13N-氨和用于心肌代谢成像的18F-氟脱氧葡萄糖（FDG）。通过13N-氨动态PET扫描和房室模型分析测量局部心肌血流量，可用于冠状动脉狭窄病变的功能评估以及肥厚性心脏病、家族性高胆固醇血症和其他可能存在微血管病变疾病中灌注异常的检测。18F-FDG通常用于区分冠心病中缺血但存活的组织与心肌瘢痕，也用于检测心脏肿瘤和结节病累及心脏的情况。除了这两种示踪剂外，目前预计11C-乙酸盐可通过评估心脏将能量转化为外部功的效率，为心力衰竭的病理生理临床分析提供帮助。
