Biasi D, Caramaschi P, Carletto A, Pacor M L, Zeminian S, Bambara L M
Istituto di Patologia Speciale Medica, Università, Verona.
Recenti Prog Med. 1998 Jan;89(1):14-7.
The aim of our study is to evaluate the efficacy and safety of a combination therapy with hydroxycloroquine, gold sodium thiomalate and methotrexate in patients affected by recent onset active rheumatoid arthritis. Twenty-five patients (6 men e 19 women, average age 46.2 +/- 12.2) were enrolled in this study and 18 of them have been treated for 1 year with the three above-mentioned drugs at optimal doses. Drug toxicity was carefully monitored. Clinical and hematochemical parameters of efficacy were evaluated every three months. Radiographic joint study was performed at the beginning and at the end of the study. Seven patients dropped out, six of them for side effects, due to hydroxycloroquine in 1 case and to gold sodium thiomalate in 5 cases; 1 patient withdrew his consent. No life-threatening or irreversible adverse reactions were observed. The eighteen patients who completed the one year trial presented a remarkable improvement of clinical and hematochemical parameters. In only 1 case one erosion appeared at the end of the study. In conclusion, the combination therapy with hydroxycloroquine, gold sodium thiomalate and methotrexate seems to be effective and burdened by an acceptable level of toxicity.
我们研究的目的是评估羟氯喹、硫代苹果酸金钠和甲氨蝶呤联合治疗对近期发病的活动性类风湿关节炎患者的疗效和安全性。本研究纳入了25名患者（6名男性和19名女性，平均年龄46.2±12.2岁），其中18名患者接受了为期1年的上述三种药物最佳剂量治疗。仔细监测药物毒性。每三个月评估一次临床和血液生化疗效参数。在研究开始和结束时进行关节影像学检查。7名患者退出研究，其中6名因副作用退出，1例因羟氯喹，5例因硫代苹果酸金钠；1名患者撤回了同意书。未观察到危及生命或不可逆的不良反应。完成一年试验的18名患者的临床和血液生化参数有显著改善。研究结束时仅1例出现一处骨质侵蚀。总之，羟氯喹、硫代苹果酸金钠和甲氨蝶呤联合治疗似乎有效，且毒性水平可接受。
