Schizophrenia as a consequence of brain evolution.

Connectionist integration of central nervous system function may have proceeded by a process of biological trial and error throughout brain evolution. As existing structures enlarged, and as new elements of brain function were added, misconnectionist variants could arise. This might account for a number of developmental syndromes in the human brain including schizophrenia. Ultimately, these would derive from aspects of hominid brain evolution and its vertebrate ancestry.