Doorduijn J K, Sonneveld P
Afd. Hematologie, Academisch Ziekenhuis Rotterdam-Dijkzigt.
Ned Tijdschr Geneeskd. 1997 Nov 8;141(45):2152-7.
Non-Hodgkin's lymphoma (NHL) is relatively frequent among elderly patients: more than half of the diagnoses in the Netherlands concern patients aged 65 years or above. The treatment depends on histological type, clinical stage and prognostic group. Increasingly, a treatment decision is made after determination of the prognostic group on the basis of the expected response and survival. In elderly patients intensive treatment frequently has more toxic effects. The expected gain in survival has to be weighed against more toxicity and loss of quality of life during and after the therapy. This is notably important for patients with low grade NHL, which requires only intermittent treatment. It is possible to cure some elderly patients with NHL of intermediate or high grade malignancy provided they are adequately treated with combination chemotherapy. Patients with low grade NHL or poor clinical condition may benefit temporarily from palliative treatment, in the planning of which quality of life has to be taken into account.
非霍奇金淋巴瘤（NHL）在老年患者中相对常见：在荷兰，超过一半的确诊病例涉及65岁及以上的患者。治疗取决于组织学类型、临床分期和预后分组。越来越多地，在根据预期反应和生存率确定预后分组后做出治疗决策。在老年患者中，强化治疗往往有更多的毒性作用。必须将预期的生存获益与治疗期间及之后更多的毒性和生活质量下降进行权衡。这对于仅需间歇性治疗的低度NHL患者尤为重要。只要采用联合化疗进行充分治疗，一些中度或高度恶性NHL的老年患者有可能治愈。低度NHL或临床状况较差的患者可能会从姑息治疗中暂时获益，在规划姑息治疗时必须考虑生活质量。
