The MAP kinase cascade: its role in Xenopus oocytes, eggs and embryos.

Mitogen-activated protein kinase (MAPK) was originally identified as a serine/threonine kinase that is activated by mitogens. Now MAPK and its activator, MAPK kinase (MAPKK), are thought to function in a wide variety of intracellular signalling pathways from yeast to vertebrate. We describe here a brief summary of the dissection of the MAPK cascade and its possible functions, especially in Xenopus oocytes and embryos.