构巢曲霉中G2/M转换及检查点反应过程中p34cdc2/细胞周期蛋白B H1和NIMA激酶的调控

Regulation of p34cdc2/cyclinB H1 and NIMA kinases during the G2/M transition and checkpoint responses in Aspergillus nidulans.

作者信息

Ye X S, Osmani S A

机构信息

Henry Hood Research Program, Weis Center for Research, Geisinger Clinic, Danville, PA 17822, USA.

出版信息

Prog Cell Cycle Res. 1997;3:221-32. doi: 10.1007/978-1-4615-5371-7_17.

DOI:10.1007/978-1-4615-5371-7_17

PMID:9552417

Abstract

In A. nidulans, activation of both p34cdc2/cyclinB H1 and NIMA kinases is required to initiate mitosis. These two kinases are regulated at several levels during interphase and are activated independently as protein kinases during G2. They are also targeted for negative regulation, to prevent mitosis by mitotic entry checkpoint controls, when DNA is not replicated or is damaged. Then, to initiate mitosis, they promote each other's mitotic functions to coordinately promote mitosis upon completion of interphase events. In addition, inactivation of both kinases by mitotic specific proteolysis is also required for progression through mitosis into G1.

摘要

在构巢曲霉中，启动有丝分裂需要p34cdc2/细胞周期蛋白B H1和NIMA激酶的激活。这两种激酶在分裂间期的多个水平受到调控，并在G2期作为蛋白激酶独立激活。当DNA未复制或受损时，它们也会受到负调控，通过有丝分裂进入检查点控制来阻止有丝分裂。然后，为了启动有丝分裂，它们相互促进有丝分裂功能，以便在间期事件完成后协同促进有丝分裂。此外，通过有丝分裂特异性蛋白水解使这两种激酶失活也是有丝分裂进入G1期所必需的。