Wolinsky H
Department of Medicine, Mount Sinai Hospital and Medical Center, New York, NY 10129, USA.
Semin Interv Cardiol. 1996 Mar;1(1):3-7.
Development of the first percutaneous catheters for local delivery is described. Understanding of the mechanisms by which circulating materials gain entrance to the artery wall, and the importance of hypertension in accelerating that process were crucial to the conceptual basis of these devices. The double balloon catheter and the porous balloon catheter were systematically studied to quantify the local pressure-wall penetration relationship. Designs for many new catheters that claim advantage over early models require similar systematic demonstration of their performance with normal and diseased arteries. Only in this way can this promising new technique become a clinical advance against human vascular disease.
本文描述了用于局部给药的第一代经皮导管的研发过程。了解循环物质进入动脉壁的机制以及高血压在加速这一过程中的重要性，对于这些装置的概念基础至关重要。对双球囊导管和多孔球囊导管进行了系统研究，以量化局部压力与血管壁穿透之间的关系。许多声称比早期型号更具优势的新型导管设计，需要在正常和病变动脉中对其性能进行类似的系统论证。只有这样，这项有前景的新技术才能成为对抗人类血管疾病的临床进展。
