Salmi P, Ahlenius S
Department of Psychology, Stockholm University, Sweden.
Pharmacol Toxicol. 1998 Mar;82(3):122-7. doi: 10.1111/j.1600-0773.1998.tb01410.x.
The present study was designed to examine 1) functional interactions between 5-HT1A and 5-HT2A/C receptors in thermoregulation in rats and 2) the specific involvement of 5-HT2A and 5-HT2C receptors in such interactions. The 5-HT2A/C receptor agonist DOI (0.025 1.6 mg kg-1, subcutaneously) produced a dose-dependent hyperthermia in rats, which was enhanced by addition of either of two 5-HT1A receptor antagonists, (-)-pindolol (0.5-1.0 mg kg-1, subcutaneously) or WAY-100,635 (0.1-0.4 mg kg-1, subcutaneously). Furthermore, the DOI-induced hyperthermia was counteracted by pretreatment with the 5-HT1A receptor agonist 8-OH-DPAT (0.05 mg kg-1, subcutaneously). The hyperthermia produced by DOI, alone or in combination with WAY-100,635, was fully antagonized by pretreatment with the 5-HT2A/C receptor antagonist ritanserin (1.0 mg kg-1, subcutaneously), as well as with the selective 5-HT2A receptor antagonist amperozide (2.0 mg kg-1, subcutaneously). The present results provide evidence for functional interactions between 5-HT1A and 5-HT2A receptors in temperature regulation in rats, and also suggest an important role for postsynaptic 5-HT2A receptors in the mediation of DOI-induced hyperthermia.
1）5-羟色胺1A（5-HT1A）和5-羟色胺2A/C（5-HT2A/C）受体在大鼠体温调节中的功能相互作用；2）5-HT2A和5-HT2C受体在这种相互作用中的具体参与情况。5-HT2A/C受体激动剂DOI（0.025 - 1.6毫克/千克，皮下注射）在大鼠中产生剂量依赖性体温升高，添加两种5-HT1A受体拮抗剂中的任何一种，即（-）-吲哚洛尔（0.5 - 1.0毫克/千克，皮下注射）或WAY-100,635（0.1 - 0.4毫克/千克，皮下注射），均可增强这种体温升高。此外，DOI诱导的体温升高可被5-HT1A受体激动剂8-OH-DPAT（0.05毫克/千克，皮下注射）预处理所抵消。DOI单独或与WAY-100,635联合产生的体温升高，可被5-HT2A/C受体拮抗剂利坦色林（1.0毫克/千克，皮下注射）以及选择性5-HT2A受体拮抗剂安匹哌唑（2.0毫克/千克，皮下注射）预处理完全拮抗。本研究结果为5-HT1A和5-HT2A受体在大鼠体温调节中的功能相互作用提供了证据，也表明突触后5-HT2A受体在介导DOI诱导的体温升高中起重要作用。
