Roberge R J, Srinivasa N S, Frank L R, Scorza L, Krenzelok E P
Department of Emergency Medicine, Western Pennsylvania Hospital, Pittsburgh 15224, USA.
Vet Hum Toxicol. 1998 Apr;40(2):95-8.
Methanol toxicity can cause severe central nervous system insult in which a characteristic pattern of bilateral putaminal injury is noted on brain imaging studies. We present a fatal case of subacute methanol toxicity with associated diffuse brain involvement, including bilateral putaminal necrosis and cerebral edema with ventricular compression. Theoretical basal ganglia toxicologic mechanisms of methanol poisoning are reviewed, and the role of brain imaging studies will regard to diagnosis, prognosis and impact on management is discussed.
甲醇中毒可导致严重的中枢神经系统损伤，脑部影像学研究显示出双侧壳核损伤的特征性模式。我们报告一例亚急性甲醇中毒致死病例，伴有弥漫性脑受累，包括双侧壳核坏死和伴有脑室受压的脑水肿。回顾了甲醇中毒的理论基底节毒理学机制，并讨论了脑部影像学研究在诊断、预后及对治疗的影响方面的作用。
