Reitmayr P
Gerontology. 1976;22(6):449-60. doi: 10.1159/000212157.
When applying various concentrations of NaC104 (0.15-7 M) to tendon fibres from rat tails, we found denaturation beginning at 2M, and with increasing concentration a linear increase of the maximal contraction tension and an expoential shortening of the contraction time down to a minimal value of 7.5 min. In a second group of experiments we investigated the weight changes of tendons of old (26-30 months) and young (8 months) rats treated with 5M NaC104 and compared the weight curves and the tension curves. We found an increase in weight up to 900% as the tension decreased. This indicates a connection between the swelling and the relaxation of collagen fibres. Other solutions of neutral salts (5M NaC103, NaC1; 0.15 M NaC104, NaC103, NaC1) tested on young and old tendons did not produce any tension nor other visible changes. The weight curves show an immediate increase up to about 200% which remains constant and which is low compaired with the effect of 5M NaC104. The reason for the contraction of tendon fivres seems to be the denaturation caused by the increased lipophilia of the aqueous salt solutions, while the relaxation is merely the result of the subsequent swelling of the collagen fibre.
当将各种浓度的高氯酸钠（0.15 - 7M）应用于大鼠尾巴的肌腱纤维时，我们发现变性从2M开始，并且随着浓度增加，最大收缩张力呈线性增加，收缩时间呈指数缩短，直至最小值7.5分钟。在第二组实验中，我们研究了用5M高氯酸钠处理的老年（26 - 30个月）和年轻（8个月）大鼠肌腱的重量变化，并比较了重量曲线和张力曲线。我们发现随着张力降低，重量增加高达900%。这表明胶原纤维的肿胀与松弛之间存在联系。在年轻和老年肌腱上测试的其他中性盐溶液（5M氯酸钠、氯化钠；0.15M高氯酸钠、氯酸钠、氯化钠）没有产生任何张力或其他可见变化。重量曲线显示立即增加至约200%，并保持恒定，与5M高氯酸钠的效果相比很低。肌腱纤维收缩的原因似乎是盐水溶液亲脂性增加导致的变性，而松弛仅仅是胶原纤维随后肿胀的结果。
