Stothers L, Goldenberg S L
Department of Surgery, University of British Columbia, Vancouver, Canada.
J Urol. 1998 May;159(5):1507-9. doi: 10.1097/00005392-199805000-00025.
During a prospective cohort study to determine the effectiveness of and adverse effects associated with transurethral collagen injection for treatment of stress urinary incontinence in women, we observed 3 cases of delayed allergic reaction at the skin test site associated with arthralgia.
A total of 337 women with at least a 1-year history, physical findings and urodynamic abnormalities consistent with stress urinary incontinence, who required pads or protective clothing and who had no or only grade 1 cystocele were enrolled in this prospective cohort study. Adverse effects were documented by a third party at each followup.
Delayed reaction at the skin test site occurred in 3 patients (0.9%), and was associated with arthralgias in 2.
The incidence and systemic nature of this type of reaction suggest that gluteraldehyde cross-linked collagen injection is not as innocuous as previously believed. Patients should be counseled regarding the unknown long-term outcome of this complication. Before treatment clinicians should consider double skin testing.
在一项前瞻性队列研究中，为确定经尿道注射胶原蛋白治疗女性压力性尿失禁的有效性及相关不良反应，我们观察到3例皮肤试验部位出现延迟过敏反应并伴有关节痛的病例。
共有337名女性纳入这项前瞻性队列研究，这些女性至少有1年与压力性尿失禁相符的病史、体格检查结果及尿动力学异常，需要使用尿垫或防护服，且无或仅有1级膀胱膨出。每次随访时由第三方记录不良反应。
3名患者（0.9%）在皮肤试验部位出现延迟反应，其中2例伴有关节痛。
这类反应的发生率及全身性表明，戊二醛交联胶原蛋白注射并非如先前认为的那样无害。应向患者说明这种并发症未知的长期后果。治疗前临床医生应考虑进行双重皮肤试验。
