一种新型促死亡基因DP5在发育中的小鼠神经系统中的表达模式。
Expression pattern of a novel death-promoting gene, DP5, in the developing murine nervous system.
作者信息
Kanazawa K, Imaizumi K, Mori T, Honma Y, Tojo M, Tanno Y, Yokoya S, Niwa S, Tohyama M, Takagi T, Wanaka A
机构信息
Department of Cell Science, Institute of Biomedical Sciences, Osaka University Medical School, Osaka 565, Japan.
出版信息
Brain Res Mol Brain Res. 1998 Mar 1;54(2):316-20. doi: 10.1016/s0169-328x(97)00360-4.
We examined the expression patterns of the DP5 gene, which encodes a protein with apoptosis-inducing activity, in the developing nervous system of mice. This gene was primarily expressed in the spinal motor neurons and peripheral sensory ganglia of mouse embryos and transiently in the postnatal brain, particularly in the entorhinal cortex and hippocampus. These expression patterns suggest that the DP5 gene may be involved in the apoptosis, if not all, of the developing nervous system.
我们研究了DP5基因的表达模式，该基因编码一种具有诱导凋亡活性的蛋白质，研究对象为小鼠发育中的神经系统。该基因主要在小鼠胚胎的脊髓运动神经元和外周感觉神经节中表达，在出生后的大脑中短暂表达，特别是在内嗅皮质和海马体中。这些表达模式表明，DP5基因可能参与了发育中神经系统的凋亡过程，即便不是全部。
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