d'Ercole C, Girard N, Cravello L, Boubli L, Potier A, Raybaud C, Blanc B
Service de Gynécologie-Obstétrique B, Hôpital de la Conception, Marseille, France.
Prenat Diagn. 1998 Mar;18(3):247-53.
Corpus callosum agenesis (CCA) was evaluated by ultrasound examination and magnetic resonance imaging (MRI) in 14 cases. Ultrasonography was able to suspect CCA by indirect signs but a definitive diagnosis of CCA was achieved in only four cases. MRI was able to diagnose complete CCA in 13 cases and showed absence of the posterior portion of the corpus callosum in one case. Additional neurological abnormalities including heterotopia, gyration anomaly, asymmetry of the cerebral hemispheres, and Dandy-Walker variant were documented in five cases, as well as an ocular anomaly which was present in one case, by MRI examination. Prenatal counselling for fetal agenesis of the corpus callosum is difficult as the prognosis is uncertain. The association with other cerebral abnormalities increases the likelihood of a poor outcome and ultrasonographic assessment of the fetal brain is limited. We found MRI to be a safe and useful additional procedure to complement ultrasonographic diagnosis or suspicion of CCA.
对14例病例通过超声检查和磁共振成像（MRI）评估胼胝体发育不全（CCA）。超声能够通过间接征象怀疑CCA，但仅4例确诊为CCA。MRI能够诊断13例完全性CCA，1例显示胼胝体后部缺失。MRI检查还记录了5例其他神经学异常，包括异位、脑回异常、大脑半球不对称和Dandy-Walker变异型，以及1例眼部异常。由于预后不确定，对胎儿胼胝体发育不全进行产前咨询很困难。与其他脑部异常的关联增加了不良结局的可能性，且胎儿脑部超声评估有限。我们发现MRI是一种安全且有用的辅助检查，可补充超声对CCA的诊断或怀疑。
