Kim Sung Eun, Jang Hye-In, Chang Kylie Hae-Jin, Sung Ji-Hee, Lee Jiwon, Lee Jeehun, Choi Suk-Joo, Oh Soo-Young, Roh Cheong-Rae, Kim Jong-Hwa
Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Obstet Gynecol Sci. 2017 Jan;60(1):8-17. doi: 10.5468/ogs.2017.60.1.8. Epub 2017 Jan 15.
With recent advances and frequent use of prenatal ultrasound, the antenatal diagnosis of agenesis of the corpus callosum (ACC) is not rare in obstetrics practices. However, information regarding the long-term neurological outcome remains uncertain. The aim of this study was to investigate clinical outcomes of prenatally diagnosed ACC and to analyze postnatal neurodevelopmental outcomes of ACC neonates born in our single center.
We retrospectively reviewed 56 cases of prenatally suspected ACC referred to our center.
Fifty-six fetuses were diagnosed with ACC, and 12 of those were followed-up in our center until delivery. Of the remaining 44, 7 were delivered after being referred back to the original hospital, 23 were lost to follow-up, and 14 had unknown outcomes. Among all 56, 29 were considered to have isolated ACC and 27 were considered to have non-isolated ACC. Of the 10 live fetuses delivered in our center, four had isolated ACC, three had non-isolated ACC, and the rest had outcomes unrelated to ACC. Neurodevelopmental outcome was followed-up until approximately age 3 years. Of the four with isolated ACC, three (75%) had normal neurodevelopmental outcomes.
Similar to other studies, the results of our single-center study included positive neurodevelopmental outcomes for those with isolated ACC. However, despite our endeavor to counsel patients with prenatally diagnosed ACC, the delivery rate in our center was quite low. Therefore, larger, multicenter, retrospective studies including long-term neurological development outcomes are crucial and urgently needed to provide better counseling.
随着产前超声技术的不断进步及广泛应用，胼胝体发育不全（ACC）的产前诊断在产科实践中并不罕见。然而，关于其长期神经学转归的信息仍不明确。本研究旨在调查产前诊断为ACC的临床结局，并分析在我们单中心出生的ACC新生儿的产后神经发育结局。
我们回顾性分析了转诊至本中心的56例产前疑似ACC病例。
56例胎儿被诊断为ACC，其中12例在本中心随访至分娩。其余44例中，7例转回原医院分娩，23例失访，14例结局不明。56例中，29例被认为是孤立性ACC，27例被认为是非孤立性ACC。在本中心分娩的10例活产胎儿中，4例为孤立性ACC，3例为非孤立性ACC，其余与ACC无关。对神经发育结局进行随访至约3岁。4例孤立性ACC患儿中，3例（75%）神经发育结局正常。
与其他研究相似，我们单中心研究的结果显示孤立性ACC患儿有良好的神经发育结局。然而，尽管我们努力为产前诊断为ACC的患者提供咨询，但本中心的分娩率相当低。因此，迫切需要开展更大规模的多中心回顾性研究，纳入长期神经发育结局，以提供更好的咨询服务。
