Kohler S, Rouse R V, Smoller B R
Department of Pathology, Stanford University Medical Center, California 94305, USA.
Mod Pathol. 1998 Jan;11(1):79-92.
In addition to Paget's disease, a heterogeneous group of processes with diverse histogeneses can give rise to intraepidermal pagetoid cells. These diseases share as their common denominator the presence of discrete non-Malpighian or abnormal Malpighian cells occurring singly or in nests within the epidermis. Either Pagetoid cells can represent the only histologic change, as in pagetoid squamous cell carcinoma in situ or superficial spreading malignant melanoma in situ, or they can be an expression of an associated dermal or internal malignancy, as in sebaceous carcinoma or breast carcinoma. The histologic appearance of the pagetoid cells in these diverse disorders can be quite similar, rendering the differential diagnosis difficult. A review of the entities that enter into the differential diagnosis of intraepidermal pagetoid cells is presented, emphasizing their distinguishing histologic and immunophenotypic features and differential diagnosis.
除佩吉特病外，一组具有不同组织发生学的异质性病变过程可产生表皮内佩吉特样细胞。这些疾病的共同特征是在表皮内存在单个或成巢状分布的离散性非马尔皮基细胞或异常马尔皮基细胞。佩吉特样细胞既可以是唯一的组织学改变，如原位佩吉特样鳞状细胞癌或原位浅表播散性恶性黑色素瘤，也可以是相关皮肤或内脏恶性肿瘤的一种表现，如皮脂腺癌或乳腺癌。这些不同疾病中佩吉特样细胞的组织学表现可能非常相似，这使得鉴别诊断很困难。本文对参与表皮内佩吉特样细胞鉴别诊断的疾病实体进行了综述，重点强调了它们独特的组织学和免疫表型特征以及鉴别诊断。
