Boulet L P, Chakir J, Dubé J, Laprise C, Boutet M, Laviolette M
Unité de Recherche, Centre de Pneumologie de l'Hôpital Laval, Réseau canadien des Centres d'exellence en santé respiratoire, Sainte-Foy, Canada.
Can Respir J. 1998 Jan-Feb;5(1):16-21. doi: 10.1155/1998/926439.
Asthma treatment has moved from bronchodilator therapy to an emphasis on anti-inflammatory therapy. Airway inflammation is believed to induce airway hyper-responsiveness (AHR) through the release of mediators that increase the airway response to agonists. However, the exact contribution of airway inflammation in the physiology of airway hyper-responsiveness remains undefined. Structural modifications in airways resulting from inflammation may contribute to the development and persistence of AHR and the development of asthma. This paper reviews some of the main components of airway inflammation and structural changes in asthma, and discusses how these processes may interact to modify airway function and induce respiratory symptoms.
哮喘治疗已从支气管扩张剂疗法转向强调抗炎疗法。气道炎症被认为通过释放增加气道对激动剂反应的介质来诱发气道高反应性（AHR）。然而，气道炎症在气道高反应性生理学中的确切作用仍不明确。炎症引起的气道结构改变可能有助于AHR的发生和持续以及哮喘的发展。本文综述了哮喘气道炎症的一些主要成分和结构变化，并讨论了这些过程如何相互作用以改变气道功能并诱发呼吸道症状。
