趋化因子及其在气道高反应性中的作用。
Chemokines and their role in airway hyper-reactivity.
作者信息
Blease K, Lukacs N W, Hogaboam C M, Kunkel S L
机构信息
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
出版信息
Respir Res. 2000;1(1):54-61. doi: 10.1186/rr13. Epub 2000 Jul 5.
Airway hyper-reactivity is a characteristic feature of many inflammatory lung diseases and is defined as an exaggerated degree of airway narrowing. Chemokines and their receptors are involved in several pathological processes that are believed to contribute to airway hyper-responsiveness, including recruitment and activation of inflammatory cells, collagen deposition and airway wall remodeling. These proteins are therefore thought to represent important therapeutic targets in the treatment of airway hyper-responsiveness. This review highlights the processes thought to be involved in airway hyper-responsiveness in allergic asthma, and the role of chemokines in these processes. Overall, the application of chemokines to the prevention or treatment of airway hyper-reactivity has tremendous potential.
气道高反应性是许多炎症性肺部疾病的一个特征性表现，被定义为气道狭窄程度的过度增加。趋化因子及其受体参与了多种病理过程，这些过程被认为与气道高反应性有关，包括炎症细胞的募集和激活、胶原蛋白沉积以及气道壁重塑。因此，这些蛋白质被认为是治疗气道高反应性的重要治疗靶点。本综述重点介绍了过敏性哮喘中被认为与气道高反应性有关的过程，以及趋化因子在这些过程中的作用。总体而言，趋化因子在预防或治疗气道高反应性方面具有巨大的应用潜力。
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