Steinhart H, Constantinidis J, Iro H
Universitäts-HNO-Klinik-Homburg/Saar.
HNO. 1998 Feb;46(2):135-9. doi: 10.1007/s001060050211.
In a series of 9 patients with advanced carcinomas of the posterior wall of the hypopharynx (2 patients with T2 tumors and 7 patients with T4 disease), we tried to preserve the larynx with surgical therapy. The concept of laryngeal preservation consisted of lateral pharyngotomy with free flap reconstruction of the defect created by the tumor resection. A recommendation for surgery was given to each patient with a neoplasm in the posterior pharyngeal wall and tumor extension > 6 cm in diameter. The maximum tumor diameters ranged between 6.5 cm and 12.5 cm. Reconstruction was performed in 8 cases with radial forearm flaps while a jejunal transplant was used in one case due to the extension of tumor. During each surgical procedure an attempt was made to preserve the superior laryngeal nerves and transplants were adapted exactly to the resection defects. Seven patients achieved oral swallowing within three months of surgery, while one patient needed four months to swallow orally. One patient had persistent aspiration and still needs a percutaneous gastrostomy. Six patients were decannulated successfully, so that laryngectomy was avoided during postoperative follow-up. These results show that surgical therapy of advanced carcinoma of the posterior wall of the hypopharynx is possible with preservation of the larynx. Additionally, functional outcome after treatment of these patients with free flap reconstruction is comparable to other treatment modalities, such as radiochemotherapy.
在一组9例下咽后壁晚期癌患者中(2例T2期肿瘤患者和7例T4期疾病患者),我们尝试通过手术治疗保留喉。保留喉的概念包括侧咽切开术及用游离皮瓣重建肿瘤切除后造成的缺损。对于每例下咽后壁有肿瘤且肿瘤直径延伸>6 cm的患者,我们都给出了手术建议。肿瘤最大直径在6.5 cm至12.5 cm之间。8例采用桡侧前臂皮瓣进行重建,1例因肿瘤延伸采用空肠移植。在每次手术过程中,都尝试保留喉上神经,并且移植皮瓣与切除缺损精确适配。7例患者在术后3个月内实现经口吞咽,1例患者需要4个月才能经口吞咽。1例患者持续存在误吸,仍需要经皮胃造瘘。6例患者成功拔管,因此在术后随访期间避免了行喉切除术。这些结果表明,下咽后壁晚期癌采用手术治疗并保留喉是可行的。此外,这些患者采用游离皮瓣重建治疗后的功能结果与其他治疗方式(如放化疗)相当。