Marco V, Sirvent J, Alvarez Moro J, Clavel M, Muntal M T, Bauza A
Department of Pathology, Hospital General de Catalunya, Sant Cugat, Barcelona, Spain.
Diagn Cytopathol. 1998 Apr;18(4):284-6. doi: 10.1002/(sici)1097-0339(199804)18:4<284::aid-dc7>3.0.co;2-c.
We describe the cytologic, histologic, and clinical features of two cases of melanotic schwannoma, arising in the neck and superior mediastinum, respectively. Cytologic findings in both cases included the presence of cells with heavily pigmented cytoplasm, showing long branching projections. The cells were arranged in clusters, with ill-defined boundaries. Histologic findings included interlacing fascicles of cells, with abundant melanin pigment, calcification, and necrosis. Immunohistochemical stains were positive for S. 100 protein and anti-human melanoma (HMB45). Both patients died with metastases.
我们描述了两例分别发生于颈部和上纵隔的黑色素性神经鞘瘤的细胞学、组织学及临床特征。两例的细胞学表现均包括存在胞质内色素沉着明显的细胞，这些细胞有长的分支状突起。细胞呈簇状排列，边界不清。组织学表现包括细胞呈交织状束状排列，伴有丰富的黑色素、钙化及坏死。免疫组化染色显示S-100蛋白和抗人黑色素瘤（HMB45）呈阳性。两名患者均死于转移。
