Domínguez Ugidos L J, Abenia Ingalaturre J M, Vallés Varela H, Lázaro F
Servicio de ORL, Hospital Clínico Universitario, Zaragoza.
Acta Otorrinolaringol Esp. 1998 Jan-Feb;49(1):9-13.
Eustachian tube (ET) disfunction, alone or combined with other factors, is the main source of middle ear pathogenesis and can lead to other physiopathological events that originate disease (serous otitis media, adhesive otitis, cholesteatoma). In seven Wistar rats (study group), experimental mechanical obstruction of the left Eustachian tube was performed. Using an anterior cervical incision, the osteocartilaginous junction of the ET was severed and obliterated with a bit of muscle in order to prevent rechanneling. After a period of six months, the middle ear mucosa was removed for histological study. Comparisons were made of the experimental ear and the opposite ear, as well as the ears of three rats in the control group. We compared our findings with those of other authors and reviewed experimental animal models of serous otitis media and cholesteatoma that have been used to study the influence of ET in middle ear disease.
咽鼓管（ET）功能障碍，单独或与其他因素共同作用，是中耳发病机制的主要根源，可导致引发疾病的其他生理病理事件（浆液性中耳炎、粘连性中耳炎、胆脂瘤）。在七只Wistar大鼠（研究组）中，对左侧咽鼓管进行了实验性机械阻塞。通过颈部前路切口，切断咽鼓管的骨软骨交界处，并用一小块肌肉将其闭塞，以防止再通。六个月后，取出中耳黏膜进行组织学研究。对实验侧耳朵与对侧耳朵以及对照组三只大鼠的耳朵进行了比较。我们将我们的研究结果与其他作者的结果进行了比较，并回顾了用于研究咽鼓管在中耳疾病中影响的浆液性中耳炎和胆脂瘤的实验动物模型。
