Kociecka W, Mrozewicz B, Gustowska L
Clinic of Parasitic and Tropical Diseases, K. Marcinkowski, University of Medical Sciences, Poznań, Poland.
Wiad Parazytol. 1997;43(3):309-11.
Clinical analysis and the set of laboratory studies, performed in 25 patients one, two, three or six years after surviving acute period of trichinellosis, documented complaints in 22 patients (88.0%) in the form of muscle complaints (68.2%), cardiovascular complaints (45.4%), generalized weakness (40.9%) and fatigability (31.8%). No significant alterations were demonstrated in electrocardiographic records. In 71.4% examined patients lactic dehydrogenase activity was augmented. Presence of IgG antibodies against the E/S antigen of Trichinella sp. was disclosed in 24 (96%) patients, including 22 patients (88.0%), in whom high titres of the antibodies were found. Morphological studies on muscle tissue (performed in 5 patients) disclosed alterations typical of trichinellosis in 4 patients and presence of Trichinella larvae, calcified to a significant extent, in 2 patients. The long term persistence of IgG class antibodies against Trichinella antigen in patients who survived acute period of trichinellosis a few years earlier points to a chronic antigenic stimulation, probably reflecting progressive destruction of Trichinella larvae in muscle tissue. This may also be expressed in complaints reported by the patients. The problem requires further observations and clinical studies.
对25例旋毛虫病急性期存活后1年、2年、3年或6年的患者进行了临床分析和一系列实验室研究，结果显示22例患者（88.0%）有症状，表现为肌肉症状（68.2%）、心血管症状（45.4%）、全身无力（40.9%）和易疲劳（31.8%）。心电图记录未显示明显异常。71.4%的受检患者乳酸脱氢酶活性升高。在24例（96%）患者中检测到针对旋毛虫E/S抗原的IgG抗体，其中22例（88.0%）抗体滴度较高。对肌肉组织的形态学研究（5例患者）显示，4例患者有旋毛虫病典型改变，2例患者有大量钙化的旋毛虫幼虫。几年前旋毛虫病急性期存活患者中针对旋毛虫抗原的IgG类抗体长期存在，表明存在慢性抗原刺激，这可能反映了肌肉组织中旋毛虫幼虫的渐进性破坏。这也可能表现为患者报告的症状。该问题需要进一步观察和临床研究。
