系统性硬化症患者幽门螺杆菌感染的高血清阳性率：与食管受累的关联
High seroprevalence of Helicobacter pylori infection in patients with systemic sclerosis: association with esophageal involvement.
作者信息
Yazawa N, Fujimoto M, Kikuchi K, Kubo M, Ihn H, Sato S, Tamaki T, Tamaki K
机构信息
Department of Dermatology, Faculty of Medicine, Tokyo University, Japan.
出版信息
J Rheumatol. 1998 Apr;25(4):650-3.
OBJECTIVE
To determine the prevalence and clinical relevance of Helicobacter pylori infection in patients with systemic sclerosis (SSc).
METHODS
Serum samples were obtained from 124 patients with SSc (67 with limited cutaneous SSc, 57 with diffuse cutaneous SSc). Fifty samples from age and sex matched individuals were used as controls. IgG antibodies to H. pylori infection were measured by ELISA.
RESULTS
IgG antibodies to H. pylori were found in 55.6% (69 of 124) of the patients with SSc, significantly more than in the controls. There was a significant correlation of the presence of antibodies to H. pylori with the prevalence of esophageal hypomotility in the patients with SSc (p < 0.02).
CONCLUSION
Patients with SSc have H. pylori infection at a higher prevalence than the general population. H. pylori might play a role in the development of esophageal dysfunction in SSc.
目的
确定系统性硬化症（SSc）患者幽门螺杆菌感染的患病率及其临床相关性。
方法
采集了124例SSc患者（67例局限性皮肤型SSc，57例弥漫性皮肤型SSc）的血清样本。选取50例年龄和性别匹配的个体样本作为对照。采用酶联免疫吸附测定法检测幽门螺杆菌感染的IgG抗体。
结果
124例SSc患者中，55.6%（69例）检测出幽门螺杆菌IgG抗体，显著高于对照组。SSc患者中幽门螺杆菌抗体的存在与食管动力不足的患病率显著相关（p < 0.02）。
结论
SSc患者幽门螺杆菌感染的患病率高于普通人群。幽门螺杆菌可能在SSc食管功能障碍的发生中起作用。
Zotero 插件