Lang J H, Lasser E C, Kolb W P
Invest Radiol. 1976 Jul-Aug;11(4):303-8. doi: 10.1097/00004424-197607000-00007.
Evidence is presented for the activation of serum complement by contrast media, in vitro and in vivo. Activation as a function of concentration was measured and the increasing order of effectiveness was found to be metrizamide, iothalamate, diatrizoate, acetrizoate, iodipamide and iopanoate. This order is the same as for protein binding and enzyme inhibition. The activation mechanism for iodipamide, and by inference for the other compounds, does not involve gamma-globulin aggregation. Serial daily injections in normal dogs resulted in substantial declines in serum complement over several days. Guinea pigs which were depleted of serum complement with cobra venom factor were found to be no less sensitive to lethal doses of iodipamide than those with normal complement. Implications of these findings are discussed.
有证据表明，造影剂在体外和体内均可激活血清补体。测定了激活与浓度的关系，发现有效性递增顺序为甲泛葡胺、异泛影酸盐、泛影酸盐、醋碘苯酸盐、碘番酸和碘帕醇。该顺序与蛋白质结合和酶抑制的顺序相同。碘番酸的激活机制以及由此推断的其他化合物的激活机制不涉及γ-球蛋白聚集。在正常犬中每日连续注射数天会导致血清补体大幅下降。发现用眼镜蛇毒因子耗尽血清补体的豚鼠对致死剂量碘番酸的敏感性并不低于补体正常的豚鼠。讨论了这些发现的意义。
