Speck U, Clauss W, Blumenbach L, Albrecht A
Invest Radiol. 1976 Jul-Aug;11(4):315-8. doi: 10.1097/00004424-197607000-00009.
Groups of 5 fasting male and female patients aged 32-83 years were each given 3 gm of the cholecystographic contrast medium iosumetic acid in micronized form (particle size less than 20 mum); Group I with 150 ml tea (standard administration); Group II with 500 ml tea; Group III with 150 ml tea plus 10 mg metoclopramide (Paspertin) 5 min p. admin. i.v.; and Group IV with 150 ml tea and 3 gm sodium bicarbonate. Blood samples were taken in the period up to 6 hours after administration in order to determine the iodine concentration according to the method of Juegst and Stauch. In Groups I and II maximum blood levels were reached 2.1 +/- 0.4 or 2.0 +/- 0.4 h p. admin. respectively, in Group III 1.6 +/- 0.2 h p. admin (in comparison to Group I: p less than 0.05) and in Group IV the maximum level was reached after only 0.9 +/- 0.2 h p. admin. The difference between Group IV and the other three groups is statistically significant (p less than 0.01). A half-life of 0.3 +/- 0.1 h was calculated for absorption in Group IV.
将32 - 83岁的5名空腹男性和女性患者分为一组，每组给予3克微粉化形式（粒径小于20微米）的胆囊造影剂碘海醇酸；第一组服用150毫升茶（标准给药方式）；第二组服用500毫升茶；第三组在静脉注射给药前5分钟服用150毫升茶加10毫克甲氧氯普胺（胃复安）；第四组服用150毫升茶和3克碳酸氢钠。给药后6小时内采集血样，以便根据Juegst和Stauch的方法测定碘浓度。在第一组和第二组中，分别在给药后2.1±0.4小时或2.0±0.4小时达到最高血药浓度，第三组在给药后1.6±0.2小时达到最高血药浓度（与第一组相比：p＜0.05），第四组仅在给药后0.9±0.2小时达到最高血药浓度。第四组与其他三组之间的差异具有统计学意义（p＜0.01）。计算出第四组吸收的半衰期为0.3±0.1小时。
