11,19-桥连孕激素的合成与生物活性
Synthesis and biological activity of 11,19-bridged progestins.
作者信息
Schwede W, Fritzemeier K H, Halfbrodt W, Krattenmacher R, Muhn P, Neef G, Ottow E, Schöllkopf K
机构信息
Research Laboratories of Schering AG, Berlin, Germany.
出版信息
Steroids. 1998 Mar;63(3):166-77. doi: 10.1016/s0039-128x(97)00161-x.
PMID:9558718
Abstract
A synthetic approach to 11,19-bridged progestins is described. The key step in the synthesis is a 6-endo-trig radical cyclisation. The new progestins were tested for their biological activities in vitro and in vivo and compared to those of known progestins.
摘要
描述了一种合成11,19-桥连孕激素的方法。合成中的关键步骤是6-内式-三自由基环化反应。对新的孕激素进行了体外和体内生物活性测试，并与已知孕激素的生物活性进行了比较。
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