激素对低密度脂蛋白受体基因表达的调控。
Regulation of the LDL receptor gene expression by hormones.
作者信息
Streicher R, Kotzka J, Müller-Wieland D, Krone W
机构信息
Deutsches Institut für Ernährungsforschung, Bergholz-Rehbrücke.
出版信息
Z Ernahrungswiss. 1998;37 Suppl 1:85-7.
PMID:9558734
Abstract
Promoter activity of the LDL receptor gene is stimulated by insulin and estradiol and mediated by SRE-1, which acts as a hormone sensitive cis-elemente. Using the antisense technique we reveal that SREBP-1 is selectively involved in the signal transduction pathway of insulin and IGF-I.
摘要
低密度脂蛋白受体基因的启动子活性受胰岛素和雌二醇刺激，并由作为激素敏感顺式元件的SRE-1介导。利用反义技术，我们发现固醇调节元件结合蛋白-1（SREBP-1）选择性地参与胰岛素和胰岛素样生长因子-I（IGF-I）的信号转导途径。
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