Korting G W, Gnändiger-Mezger A
Hautarzt. 1976 Jul;27(7):334-9.
Preferring to the antecedent sparse literature an observation of "dermatitis nodularis necrotica" is described in a 15 year old girl with constipation showing the typical coarse-nodular necrotizing exanthema especially on the extremities. Histologically there was a perivasculitis with prevailing excessive cellular infiltrates (reticulum cells, granulocytes). Immunological tests (immunoelectrophoresis, fluorescence-histology in skin and intestinal biopsy) were negative. On the other hand staphylococcus aureus (as detected in skin scratches and by intracutaneous tests) seemed to play an etiologic role. Thus "dermatitis nodularis necrotica", on clinical grounds somewhat similar to papulo-necrotic tuberculids, seems to be a bacteride with secundary alterations of the skin vessels and not a variant of primary vasculitis.
鉴于先前相关文献较少,本文描述了一名15岁便秘女孩出现的“坏死性结节性皮炎”,其表现为典型的粗结节坏死性皮疹,尤其在四肢。组织学检查显示为血管周围炎,主要有大量细胞浸润(网状细胞、粒细胞)。免疫测试(免疫电泳、皮肤及肠道活检的荧光组织学检查)均为阴性。另一方面,金黄色葡萄球菌(在皮肤划痕及皮内试验中检测到)似乎起病因学作用。因此,“坏死性结节性皮炎”,基于临床与丘疹坏死性结核疹有些相似,似乎是一种伴有皮肤血管继发性改变的细菌性疾病,而非原发性血管炎的一种变体。