Gonçalves L M, Ribeiro J, Isaac J, Monteiro A, Porto A, Providência L A
Cadeira de Cardiologia (Medicina II), Faculdade de Medicina, Universidade de Coimbra (FMUC).
Rev Port Cardiol. 1998 Jan;17(1):27-33.
The aim of this study was to evaluate the left ventricle filling pattern in patients with stable systemic lupus erythematosus (SLE).
This prospective study was performed in 22 healthy controls and in 24 patients with stable SLE. These two groups were submitted to a clinical, electrocardiographic and echocardiographic evaluation.
Gender distribution and mean age were similar in both groups (p = NS). Patients with SLE were more symptomatic (21%) than control patients (0%) (p < 0.01). Left ventricular dimensions, wall thickness, and systolic function were not significantly different between the two groups. However, pericardial effusion was more frequently found in patients with SLE (21%) when compared to the control group (0%) (p < 0.05). When compared to the control group, patients with SLE showed an abnormal left ventricular filling pattern. Peak late mitral flow velocity was 0.45 +/- 0.2 m/sec in SLE patients and 0.36 +/- 0.1 m/sec in the control group (p = 0.001).
These results demonstrate that patients with stable SLE, when compared to healthy controls, are frequently associated with cardiovascular symptoms, asymptomatic pericardial effusion, and an abnormal left ventricular filling pattern.
本研究旨在评估稳定期系统性红斑狼疮（SLE）患者的左心室充盈模式。
本前瞻性研究纳入了22名健康对照者和24名稳定期SLE患者。对这两组进行了临床、心电图和超声心动图评估。
两组的性别分布和平均年龄相似（p =无统计学意义）。SLE患者的症状发生率（21%）高于对照患者（0%）（p < 0.01）。两组之间的左心室尺寸、壁厚和收缩功能无显著差异。然而，与对照组（0%）相比，SLE患者的心包积液更为常见（21%）（p < 0.05）。与对照组相比，SLE患者表现出异常的左心室充盈模式。SLE患者二尖瓣晚期血流峰值速度为0.45±0.2米/秒，对照组为0.36±0.1米/秒（p = 0.001）。
这些结果表明，与健康对照者相比，稳定期SLE患者常伴有心血管症状、无症状心包积液和异常的左心室充盈模式。
