源自铜绿假单胞菌的细菌产物CANTASTIM的实验研究。II. 对鼠伤寒沙门氏菌感染的保护作用。

Experimental studies on bacterial product CANTASTIM derived from Pseudomonas aeruginosa. II. Protective effect in Salmonella typhimurium infection.

作者信息

Salageanu A, Ceacareanu B, Popescu D, Istrate N, Szegli G

机构信息

Immunology Department, Cantacuzino Institute, Bucharest, Romania.

出版信息

Roum Arch Microbiol Immunol. 1997 Jan-Jun;56(1-2):17-26.

Abstract

Stimulation of the host defense system in a nonspecific way may provide effective treatment of recurrent infections. CANTASTIM is a bacterial product that has been successfully used in cancer immunotherapy as well as in chronic infections treatment. The nonspecific protective effect of CANTASTIM was investigated in two models of experimental infection with Salmonella typhimurium in mice. Prophylactic administration of CANTASTIM (three days before challenge) enhanced peritoneal macrophages bactericidal activity and significantly increased survival of treated mice. When CANTASTIM was administered 72 h after bacterial challenge, in a sublethal infection model with Salmonella typhimurium, by activating macrophages, NK and T cells, it increased the survival rate. The cell populations and molecular mechanisms involved in the prophylactic and therapeutic protective effect CANTASTIM seem to be partially different.

摘要

以非特异性方式刺激宿主防御系统可能为复发性感染提供有效的治疗方法。CANTASTIM是一种细菌产物，已成功用于癌症免疫治疗以及慢性感染的治疗。在两种小鼠鼠伤寒沙门氏菌实验感染模型中研究了CANTASTIM的非特异性保护作用。预防性给予CANTASTIM（攻击前三天）可增强腹膜巨噬细胞的杀菌活性，并显著提高治疗小鼠的存活率。当在鼠伤寒沙门氏菌亚致死感染模型中细菌攻击后72小时给予CANTASTIM时，通过激活巨噬细胞、自然杀伤细胞和T细胞，它提高了存活率。CANTASTIM预防性和治疗性保护作用所涉及的细胞群体和分子机制似乎部分不同。

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