Guirguitzova B, Chankova D, Zozikov B, Minkov N
Ann Urol (Paris). 1998;32(1):15-9.
221 clinically significant enterococcal strains (191: E. faecalis, 27: E. faecium, 3 others) were isolated from the urine of patients hospitalised with UTI over an 18-month period (1995-1996). The susceptibility of the isolates to 8 antimicrobial agents was determined by agar dilution method (NCCLS). All enterococci were sensitive to vancomycin and most of them (over 92%) to penicillin and ampicillin. Only 3.14% of E. faecalis and 3.70% of E. faecium were resistant to ciprofloxacin. A relatively high incidence of resistance of enterococci to aminoglycosides was observed: 46.07% and 51.85% to streptomycin, 42.41% and 44.44% to gentamicin, 70.68% and 77.78% to amikacin for E. faecalis and E. faecium, respectively. Among the resistant to penicillin and amino glycosides enterococci of the two species was found a great percent "high level" resistance. There were no beta-lactamase producers among our strains. The established multiresistance accompanied by "high level" resistance requires careful consideration of antimicrobial therapy of enterococcal UTI.
在18个月期间(1995 - 1996年),从因尿路感染住院的患者尿液中分离出221株具有临床意义的肠球菌菌株(191株粪肠球菌、27株屎肠球菌、3株其他菌株)。采用琼脂稀释法(NCCLS)测定分离菌株对8种抗菌药物的敏感性。所有肠球菌对万古霉素敏感,大多数(超过92%)对青霉素和氨苄西林敏感。仅3.14%的粪肠球菌和3.70%的屎肠球菌对环丙沙星耐药。观察到肠球菌对氨基糖苷类药物的耐药发生率相对较高:粪肠球菌对链霉素的耐药率为46.07%,对庆大霉素为42.41%,对阿米卡星为70.68%;屎肠球菌对链霉素的耐药率为51.85%,对庆大霉素为44.44%,对阿米卡星为77.78%。在对青霉素和氨基糖苷类耐药的两种肠球菌中,发现有很大比例的“高水平”耐药。我们的菌株中没有β-内酰胺酶产生菌。已确定的多重耐药伴“高水平”耐药需要在治疗肠球菌性尿路感染时仔细考虑抗菌治疗方案。