Ashby M N
Acacia Biosciences Inc., Richmond, CA 94806, USA.
Curr Opin Lipidol. 1998 Apr;9(2):99-102. doi: 10.1097/00041433-199804000-00004.
Proteins that contain a carboxyl-terminal CaaX motif undergo post-translational processing involving prenylation, endoproteolysis and methylesterification. Two yeast genes, AFC1 and RCE1, which are candidates for genes encoding CaaX converting enzymes, were recently identified. Rce1p is required for the full penetrance of the activated Ras2pval19 phenotype in yeast, indicating its possible utility as a new target in Ras-based malignancies. Advances in our current understanding of CaaX convertases and the functional importance of CaaX proteolysis are discussed.
含有羧基末端CaaX基序的蛋白质会经历包括异戊二烯化、内切蛋白水解和甲基酯化在内的翻译后加工过程。最近鉴定出了两个酵母基因AFC1和RCE1，它们是编码CaaX转换酶的基因候选者。Rce1p对于酵母中激活的Ras2pval19表型的完全外显是必需的，这表明它可能作为基于Ras的恶性肿瘤中的一个新靶点。本文讨论了我们目前对CaaX转换酶的理解进展以及CaaX蛋白水解的功能重要性。
