不育男性临床精索静脉曲张的病理生理学

Pathophysiology of clinical varicoceles in infertile men.

作者信息

Cockett A T, Takihara H, Iwamura M, Koshiba K

机构信息

Department of Urology, University of Rochester Medical Center, New York 14642-8656, USA.

出版信息

Int J Urol. 1998 Mar;5(2):113-5. doi: 10.1111/j.1442-2042.1998.tb00256.x.

DOI:10.1111/j.1442-2042.1998.tb00256.x

PMID:9559833

Abstract

In infertile men, clinical varicoceles most often occur bilaterally. In our experience with these patients, both testicles are smaller than normal. We find more than 25% to 35% immature and tapered sperm in in the ejaculum of these men, and the motility of the sperm is usually low. We have found serotonin in the plasma of the varicoceles, and believe this biogenic amine is responsible for the poor sperm motility. We now agree that a subset of neuroendocrine cells in the prostate secrete serotonin. Bilateral varicocele surgery can improve the patient's fertility potential, and we advocate surgical treatment.

摘要

在不育男性中，临床型精索静脉曲张最常双侧发生。根据我们对这些患者的经验，双侧睾丸均小于正常大小。我们发现这些男性的射精精液中有超过25%至35%的未成熟和锥形精子，并且精子活力通常较低。我们在精索静脉曲张患者的血浆中发现了血清素，并认为这种生物胺是精子活力差的原因。我们现在认同前列腺中的一部分神经内分泌细胞会分泌血清素。双侧精索静脉曲张手术可以提高患者的生育潜力，我们主张进行手术治疗。